Items where Author or Contributor is "Fletcher, Helen"
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Number of items: 121.
2021
Ogbe, Ane;
Kronsteiner, Barbara;
Skelly, Donal T;
Pace, Matthew;
Brown, Anthony;
Adland, Emily;
Adair, Kareena;
Akhter, Hossain Delowar;
Ali, Mohammad;
Ali, Serat-E;
+53 more...
Angyal, Adrienn;
Ansari, M Azim;
Arancibia-Cárcamo, Carolina V;
Brown, Helen;
Chinnakannan, Senthil;
Conlon, Christopher;
de Lara, Catherine;
de Silva, Thushan;
Dold, Christina;
Dong, Tao;
Donnison, Timothy;
Eyre, David;
Flaxman, Amy;
Fletcher, Helen;
Gardner, Joshua;
Grist, James T;
Hackstein, Carl-Philipp;
Jaruthamsophon, Kanoot;
Jeffery, Katie;
Lambe, Teresa;
Lee, Lian;
Li, Wenqin;
Lim, Nicholas;
Matthews, Philippa C;
Mentzer, Alexander J;
Moore, Shona C;
Naisbitt, Dean J;
Ogese, Monday;
Ogg, Graham;
Openshaw, Peter;
Pirmohamed, Munir;
Pollard, Andrew J;
Ramamurthy, Narayan;
Rongkard, Patpong;
Rowland-Jones, Sarah;
Sampson, Oliver;
Screaton, Gavin;
Sette, Alessandro;
Stafford, Lizzie;
Thompson, Craig;
Thomson, Paul J;
Thwaites, Ryan;
Vieira, Vinicius;
Weiskopf, Daniela;
Zacharopoulou, Panagiota;
Oxford Immunology Network Covid-19 Response T Cell Consortium;
Oxford Protective T Cell Immunology for COVID-19 (OPTIC) Clinica;
Turtle, Lance;
Klenerman, Paul;
Goulder, Philip;
Frater, John;
Barnes, Eleanor;
Dunachie, Susanna;
Oxford Immunology Network Covid-19 Response T Cell Consortium, Oxford Protective T Cell Immunology for COVID-19 (OPTIC) Clinica;
(2021)
T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses.
Nature communications, 12 (1).
2055-.
ISSN 2041-1723
DOI: https://doi.org/10.1038/s41467-021-21856-3
Olbrich, Laura;
Stockdale, Lisa;
Basu Roy, Robindra;
Song, Rinn;
Cicin-Sain, Luka;
Whittaker, Elizabeth;
Prendergast, Andrew J;
Fletcher, Helen;
Seddon, James A;
(2021)
Understanding the interaction between cytomegalovirus and tuberculosis in children: The way forward.
PLOS PATHOGENS, 17 (12).
e1010061-.
ISSN 1553-7366
DOI: https://doi.org/10.1371/journal.ppat.1010061
Painter, HE;
(2021)
Accelerating the preclinical development of effective vaccines for protection against Mycobacterium tuberculosis.
PhD thesis, London School of Hygiene & Tropical Medicine.
DOI: https://doi.org/10.17037/PUBS.04665079
Sarfas, Charlotte;
White, Andrew D;
Sibley, Laura;
Morrison, Alexandra L;
Gullick, Jennie;
Lawrence, Steve;
Dennis, Mike J;
Marsh, Philip D;
Fletcher, Helen A;
Sharpe, Sally A;
(2021)
Characterization of the Infant Immune System and the Influence and Immunogenicity of BCG Vaccination in Infant and Adult Rhesus Macaques.
Frontiers in immunology, 12.
754589-.
ISSN 1664-3224
DOI: https://doi.org/10.3389/fimmu.2021.754589
Tanner, Rachel;
Hoogkamer, Emily;
Bitencourt, Julia;
White, Andrew;
Boot, Charelle;
Sombroek, Claudia C;
Harris, Stephanie A;
O'Shea, Matthew K;
Wright, Daniel;
Wittenberg, Rachel;
+6 more...
Sarfas, Charlotte;
Satti, Iman;
Verreck, Frank AW;
Sharpe, Sally A;
Fletcher, Helen A;
McShane, Helen;
(2021)
The in vitro direct mycobacterial growth inhibition assay (MGIA) for the early evaluation of TB vaccine candidates and assessment of protective immunity: a protocol for non-human primate cells.
F1000Research, 10.
257-.
ISSN 2046-1402
DOI: https://doi.org/10.12688/f1000research.51640.2
Tanner, Rachel;
White, Andrew D;
Boot, Charelle;
Sombroek, Claudia C;
O'Shea, Matthew K;
Wright, Daniel;
Hoogkamer, Emily;
Bitencourt, Julia;
Harris, Stephanie A;
Sarfas, Charlotte;
+6 more...
Wittenberg, Rachel;
Satti, Iman;
Fletcher, Helen A;
Verreck, Frank AW;
Sharpe, Sally A;
McShane, Helen;
(2021)
A non-human primate in vitro functional assay for the early evaluation of TB vaccine candidates.
NPJ vaccines, 6 (1).
3-.
ISSN 2059-0105
DOI: https://doi.org/10.1038/s41541-020-00263-7
2020
Chaichana, Panjaporn;
Kronsteiner, Barbara;
Rongkard, Patpong;
Teparrukkul, Prapit;
Limmathurotsakul, Direk;
Chantratita, Narisara;
Day, Nicholas PJ;
Fletcher, Helen A;
Dunachie, Susanna J;
(2020)
Serum From Melioidosis Survivors Diminished Intracellular Burkholderia pseudomallei Growth in Macrophages: A Brief Research Report.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 10.
442-.
ISSN 2235-2988
DOI: https://doi.org/10.3389/fcimb.2020.00442
Hayward, Sally E;
Dowd, Jennifer B;
Fletcher, Helen;
Nellums, Laura B;
Wurie, Fatima;
Boccia, Delia;
(2020)
A systematic review of the impact of psychosocial factors on immunity: Implications for enhancing BCG response against tuberculosis.
SSM - Population Health, 10.
100522-.
ISSN 2352-8273
DOI: https://doi.org/10.1016/j.ssmph.2019.100522
Painter, Hannah;
Prabowo, Satria A;
Cia, Felipe;
Stockdale, Lisa;
Tanner, Rachel;
Willcocks, Samuel;
Reljic, Rajko;
Fletcher, Helen A;
Zelmer, Andrea;
(2020)
Adaption of the ex vivo mycobacterial growth inhibition assay for use with murine lung cells.
Scientific Reports, 10 (1).
3311-.
DOI: https://doi.org/10.1038/s41598-020-60223-y
Rongkard, Patpong;
Kronsteiner, Barbara;
Hantrakun, Viriya;
Jenjaroen, Kemajittra;
Sumonwiriya, Manutsanun;
Chaichana, Panjaporn;
Chumseng, Suchintana;
Chantratita, Narisara;
Wuthiekanun, Vanaporn;
Fletcher, Helen A;
+4 more...
Teparrukkul, Prapit;
Limmathurotsakul, Direk;
Day, Nicholas PJ;
Dunachie, Susanna J;
(2020)
Human Immune Responses to Melioidosis and Cross-Reactivity to Low-Virulence Burkholderia Species, Thailand1.
EMERGING INFECTIOUS DISEASES, 26 (3).
pp. 463-471.
ISSN 1080-6040
DOI: https://doi.org/10.3201/eid2603.190206
Tanner, Rachel;
Satti, Iman;
Harris, Stephanie A;
O'Shea, Matthew K;
Cizmeci, Deniz;
O'Connor, Daniel;
Chomka, Agnieszka;
Matsumiya, Magali;
Wittenberg, Rachel;
Minassian, Angela M;
+3 more...
Meyer, Joel;
Fletcher, Helen A;
McShane, Helen;
(2020)
Tools for Assessing the Protective Efficacy of TB Vaccines in Humans: in vitro Mycobacterial Growth Inhibition Predicts Outcome of in vivo Mycobacterial Infection.
FRONTIERS IN IMMUNOLOGY, 10.
2983-.
ISSN 1664-3224
DOI: https://doi.org/10.3389/fimmu.2019.02983
2019
Khan, Mishal S;
Rahman-Shepherd, Afifah;
Painter, Hannah;
Fletcher, Helen;
(2019)
How can we improve priority-setting for investments in health research? A case study of tuberculosis.
Health Research Policy and Systems, 17 (1).
68-.
ISSN 1478-4505
DOI: https://doi.org/10.1186/s12961-019-0473-7
Lee, Hyejon;
Kim, Jungho;
Kang, Young Ae;
Kim, Deok Ryun;
Sim, Bora;
Zelmer, Andrea;
Fletcher, Helen A;
Dockrell, Hazel M;
Smith, Steven G;
Cho, Sang-Nae;
(2019)
In vitro Mycobacterial Growth Inhibition in South Korean Adults With Latent TB Infection.
Frontiers in Immunology, 10 (APR).
896-.
DOI: https://doi.org/10.3389/fimmu.2019.00896
Müller, Julius;
Tanner, Rachel;
Matsumiya, Magali;
Snowden, Margaret A;
Landry, Bernard;
Satti, Iman;
Harris, Stephanie A;
O'Shea, Matthew K;
Stockdale, Lisa;
Marsay, Leanne;
+16 more...
Chomka, Agnieszka;
Harrington-Kandt, Rachel;
Thomas, Zita-Rose Manjaly;
Naranbhai, Vivek;
Stylianou, Elena;
Mbandi, Stanley Kimbung;
Hatherill, Mark;
Hussey, Gregory;
Mahomed, Hassan;
Tameris, Michele;
McClain, J Bruce;
Evans, Thomas G;
Hanekom, Willem A;
Scriba, Thomas J;
McShane, Helen;
Fletcher, Helen A;
(2019)
Cytomegalovirus infection is a risk factor for tuberculosis disease in infants.
JCI insight, 4 (23).
ISSN 2379-3708
DOI: https://doi.org/10.1172/jci.insight.130090
Prabowo, SA;
(2019)
Accelerating Development of Therapeutic Tuberculosis Vaccines Using an Ex Vivo Immune Assay Platform.
PhD (research paper style) thesis, London School of Hygiene & Tropical Medicine.
DOI: https://doi.org/10.17037/PUBS.04652085
Prabowo, Satria A;
Painter, Hannah;
Zelmer, Andrea;
Smith, Steven G;
Seifert, Karin;
Amat, Merce;
Cardona, Pere-Joan;
Fletcher, Helen A;
(2019)
RUTI Vaccination Enhances Inhibition of Mycobacterial Growth ex vivo and Induces a Shift of Monocyte Phenotype in Mice.
Frontiers in Immunology, 10 (APR).
894-.
DOI: https://doi.org/10.3389/fimmu.2019.00894
Prabowo, Satria A;
Smith, Steven G;
Seifert, Karin;
Fletcher, Helen A;
(2019)
Impact of individual-level factors on Ex vivo mycobacterial growth inhibition: Associations of immune cell phenotype, cytomegalovirus-specific response and sex with immunity following BCG vaccination in humans.
Tuberculosis, 119.
101876-.
ISSN 1472-9792
DOI: https://doi.org/10.1016/j.tube.2019.101876
Prabowo, Satria A;
Zelmer, Andrea;
Stockdale, Lisa;
Ojha, Utkarsh;
Smith, Steven G;
Seifert, Karin;
Fletcher, Helen A;
(2019)
Historical BCG vaccination combined with drug treatment enhances inhibition of mycobacterial growth ex vivo in human peripheral blood cells.
SCIENTIFIC REPORTS, 9 (1).
4842-.
ISSN 2045-2322
DOI: https://doi.org/10.1038/s41598-019-41008-4
Sibley, Laura;
Gooch, Karen;
Wareham, Alice;
Gray, Susan;
Chancellor, Andrew;
Dowall, Stuart;
Bate, Simon;
Marriott, Anthony;
Dennis, Mike;
White, Andrew D;
+3 more...
Marsh, Philip D;
Fletcher, Helen;
Sharpe, Sally;
(2019)
Differences in monocyte: lymphocyte ratio and Tuberculosis disease progression in genetically distinct populations of macaques.
Scientific reports, 9 (1).
3340-.
ISSN 2045-2322
DOI: https://doi.org/10.1038/s41598-019-39819-6
Stockdale, L;
(2019)
Investigation of immune correlates, and impact of human cytomegalovirus and immune activation, on tuberculosis disease risk.
PhD (research paper style) thesis, London School of Hygiene & Tropical Medicine.
DOI: https://doi.org/10.17037/PUBS.04652176
Stockdale, Lisa;
Nash, Stephen;
Farmer, Ruth;
Raynes, John;
Mallikaarjun, Suresh;
Newton, Robert;
Fletcher, Helen A;
(2019)
Cytomegalovirus Antibody Responses Associated With Increased Risk of Tuberculosis Disease in Ugandan Adults.
The Journal of infectious diseases, 221 (7).
pp. 1127-1134.
ISSN 0022-1899
DOI: https://doi.org/10.1093/infdis/jiz581
2018
Cobelens, Frank;
Nagelkerke, Nico;
Fletcher, Helen;
(2018)
The convergent epidemiology of tuberculosis and human cytomegalovirus infection.
F1000Research, 7.
p. 280.
DOI: https://doi.org/10.12688/f1000research.14184.2
Cobelens, Frank;
Nagelkerke, Nico;
Fletcher, Helen;
(2018)
The convergent epidemiology of tuberculosis and human cytomegalovirus infection.
F1000Research, 7.
280-.
ISSN 2046-1402
DOI: https://doi.org/10.12688/f1000research.14184.2
Dowd, Jennifer B;
Fletcher, Helen A;
Boccia, Delia;
(2018)
Social determinants and BCG efficacy: a call for a socio-biological approach to TB prevention.
F1000Research, 7.
224-.
ISSN 2046-1402
DOI: https://doi.org/10.12688/f1000research.14085.1
Fletcher, Helen A;
(2018)
Systems approaches to correlates of protection and progression to TB disease.
Seminars in immunology, 39 (C).
pp. 81-87.
ISSN 1044-5323
DOI: https://doi.org/10.1016/j.smim.2018.10.001
Full text not available from this repository.
Fletcher, Helen A;
Chatterjee, Mitali;
Cooper, Andrea;
Hussell, Tracy;
Kaye, Paul M;
Prior, Joann;
Reljic, Rajko;
Vermaak, Samantha;
Vordermeier, Martin;
Williams, Ann;
+1 more...
McShane, Helen;
(2018)
VALIDATE: Exploiting the synergy between complex intracellular pathogens to expedite vaccine research and development for tuberculosis, leishmaniasis, melioidosis and leprosy.
F1000Research, 7.
485-.
ISSN 2046-1402
DOI: https://doi.org/10.12688/f1000research.14386.1
Gupta-Wright, Ankur;
Tomlinson, Gillian S;
Rangaka, Molebogeng X;
Fletcher, Helen A;
(2018)
World TB Day 2018: The Challenge of Drug Resistant Tuberculosis.
F1000Research, 7.
217-.
ISSN 2046-1402
DOI: https://doi.org/10.12688/f1000research.14088.1
Kewcharoenwong, Chidchamai;
Prabowo, Satria A;
Bancroft, Gregory J;
Fletcher, Helen A;
Lertmemongkolchai, Ganjana;
(2018)
Glibenclamide Reduces Primary Human Monocyte Functions Against Tuberculosis Infection by Enhancing M2 Polarization.
Frontiers in immunology, 9 (SEP).
2109-.
ISSN 1664-3224
DOI: https://doi.org/10.3389/fimmu.2018.02109
McNeill, Eileen;
Stylianou, Elena;
Crabtree, Mark J;
Harrington-Kandt, Rachel;
Kolb, Anna-Lena;
Diotallevi, Marina;
Hale, Ashley B;
Bettencourt, Paulo;
Tanner, Rachel;
O'Shea, Matthew K;
+7 more...
Matsumiya, Magali;
Lockstone, Helen;
Müller, Julius;
Fletcher, Helen A;
Greaves, David R;
McShane, Helen;
Channon, Keith M;
(2018)
Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin.
NATURE COMMUNICATIONS, 9 (1).
5409-.
ISSN 2041-1723
DOI: https://doi.org/10.1038/s41467-018-07714-9
Rhodes, SJ;
(2018)
The development of a mathematical modelling framework to translate TB vaccine responses between species and predict the most immunogenic dose in humans using animal data.
PhD (research paper style) thesis, London School of Hygiene & Tropical Medicine.
DOI: https://doi.org/10.17037/PUBS.04647153
Rhodes, Sophie J;
Guedj, Jeremie;
Fletcher, Helen A;
Lindenstrøm, Thomas;
Scriba, Thomas J;
Evans, Thomas G;
Knight, Gwenan M;
White, Richard G;
(2018)
Using vaccine Immunostimulation/Immunodynamic modelling methods to inform vaccine dose decision-making.
NPJ Vaccines, 3 (1).
36-.
ISSN 2059-0105
DOI: https://doi.org/10.1038/s41541-018-0075-3
Stockdale, Lisa;
Nash, Stephen;
Nalwoga, Angela;
Gibson, Lorna;
Painter, Hannah;
Raynes, John;
Asiki, Gershim;
Newton, Robert;
Fletcher, Helen;
(2018)
HIV, HCMV and mycobacterial antibody levels: a cross-sectional study in a rural Ugandan cohort.
Tropical Medicine & International Health, 24 (2).
pp. 247-257.
ISSN 1360-2276
DOI: https://doi.org/10.1111/tmi.13188
Stockdale, Lisa;
Nash, Stephen;
Nalwoga, Angela;
Painter, Hannah;
Asiki, Gershim;
Fletcher, Helen;
Newton, Robert;
(2018)
Human cytomegalovirus epidemiology and relationship to tuberculosis and cardiovascular disease risk factors in a rural Ugandan cohort.
PloS one, 13 (2).
e0192086-.
ISSN 1932-6203
DOI: https://doi.org/10.1371/journal.pone.0192086
Voss, Gerald;
Casimiro, Danilo;
Neyrolles, Olivier;
Williams, Ann;
Kaufmann, Stefan HE;
McShane, Helen;
Hatherill, Mark;
Fletcher, Helen A;
(2018)
Progress and challenges in TB vaccine development.
F1000Research, 7.
199-.
ISSN 2046-1402
DOI: https://doi.org/10.12688/f1000research.13588.1
Zelmer, Andrea;
Stockdale, Lisa;
Prabowo, Satria A;
Cia, Felipe;
Spink, Natasha;
Gibb, Matthew;
Eddaoudi, Ayad;
Fletcher, Helen A;
(2018)
High monocyte to lymphocyte ratio is associated with impaired protection after subcutaneous administration of BCG in a mouse model of tuberculosis.
F1000Research, 7.
p. 296.
DOI: https://doi.org/10.12688/f1000research.14239.2
Zelmer, Andrea;
Stockdale, Lisa;
Prabowo, Satria A;
Cia, Felipe;
Spink, Natasha;
Gibb, Matthew;
Eddaoudi, Ayad;
Fletcher, Helen A;
(2018)
High monocyte to lymphocyte ratio is associated with impaired protection after subcutaneous administration of BCG in a mouse model of tuberculosis.
F1000Research, 7.
296-.
ISSN 2046-1402
DOI: https://doi.org/10.12688/f1000research.14239.2
2017
Andrews, Jason R;
Nemes, Elisa;
Tameris, Michele;
Landry, Bernard S;
Mahomed, Hassan;
McClain, J Bruce;
Fletcher, Helen A;
Hanekom, Willem A;
Wood, Robin;
McShane, Helen;
+2 more...
Scriba, Thomas J;
Hatherill, Mark;
(2017)
Serial QuantiFERON testing and tuberculosis disease risk among young children: an observational cohort study.
The lancet Respiratory medicine, 5 (4).
pp. 282-290.
ISSN 2213-2600
DOI: https://doi.org/10.1016/S2213-2600(17)30060-7
Brennan, Michael J;
Tanner, Rachel;
Morris, Sheldon;
Scriba, Thomas J;
Achkar, Jacqueline M;
Zelmer, Andrea;
Hokey, David A;
Izzo, Angelo;
Sharpe, Sally;
Williams, Ann;
+6 more...
Penn-Nicholson, Adam;
Erasmus, Mzwandile;
Stylianou, Elena;
Hoft, Daniel F;
McShane, Helen;
Fletcher, Helen A;
(2017)
The Cross-Species Mycobacterial Growth Inhibition Assay (MGIA) Project, 2010-2014.
Clinical and vaccine immunology, 24 (9).
ISSN 1556-6811
DOI: https://doi.org/10.1128/CVI.00142-17
Rhodes, Sophie J;
Sarfas, Charlotte;
Knight, Gwenan M;
White, Andrew;
Pathan, Ansar A;
McShane, Helen;
Evans, Thomas G;
Fletcher, Helen;
Sharpe, Sally;
White, Richard G;
(2017)
Using Data from Macaques To Predict Gamma Interferon Responses after Mycobacterium bovis BCG Vaccination in Humans: a Proof-of-Concept Study of Immunostimulation/Immunodynamic Modeling Methods.
Clinical and vaccine immunology, 24 (3).
ISSN 1556-6811
DOI: https://doi.org/10.1128/CVI.00525-16
Scriba, Thomas J;
Coussens, Anna K;
Fletcher, Helen A;
(2017)
Human Immunology of Tuberculosis.
Microbiology Spectrum, 4 (5).
24-.
DOI: https://doi.org/10.1128/microbiolspec.TBTB2-0016-2016
Full text not available from this repository.
Scriba, Thomas J;
Coussens, Anna K;
Fletcher, Helen A;
(2017)
Human Immunology of Tuberculosis.
Microbiology Spectrum, 5 (1).
ISSN 2165-0497
DOI: https://doi.org/10.1128/microbiolspec.tbtb2-0016-2016
Tanner, Rachel;
O'Shea, Matthew K;
White, Andrew D;
Müller, Julius;
Harrington-Kandt, Rachel;
Matsumiya, Magali;
Dennis, Mike J;
Parizotto, Eneida A;
Harris, Stephanie;
Stylianou, Elena;
+6 more...
Naranbhai, Vivek;
Bettencourt, Paulo;
Drakesmith, Hal;
Sharpe, Sally;
Fletcher, Helen A;
McShane, Helen;
(2017)
The influence of haemoglobin and iron on in vitro mycobacterial growth inhibition assays.
Scientific reports, 7 (1).
43478-.
ISSN 2045-2322
DOI: https://doi.org/10.1038/srep43478
2016
Abubakar, Ibrahim;
Lipman, Marc;
McHugh, Timothy D;
Fletcher, Helen;
(2016)
Uniting to end the TB epidemic: advances in disease control from prevention to better diagnosis and treatment.
BMC medicine, 14 (1).
47-.
ISSN 1741-7015
DOI: https://doi.org/10.1186/s12916-016-0599-1
Chen, Tingting;
Blanc, Caroline;
Eder, Anke Z;
Prados-Rosales, Rafael;
Souza, Ana Camila Oliveira;
Kim, Ryung S;
Glatman-Freedman, Aharona;
Joe, Maju;
Bai, Yu;
Lowary, Todd L;
+6 more...
Tanner, Rachel;
Brennan, Michael J;
Fletcher, Helen A;
McShane, Helen;
Casadevall, Arturo;
Achkar, Jacqueline M;
(2016)
Association of Human Antibodies to Arabinomannan With Enhanced Mycobacterial Opsonophagocytosis and Intracellular Growth Reduction.
The Journal of infectious diseases, 214 (2).
pp. 300-310.
ISSN 0022-1899
DOI: https://doi.org/10.1093/infdis/jiw141
Fletcher, Helen A;
(2016)
Sleeping Beauty and the Story of the Bacille Calmette-Guérin Vaccine.
mBio, 7 (4).
ISSN 2150-7511
DOI: https://doi.org/10.1128/mBio.01370-16
Fletcher, Helen A;
Dockrell, Hazel M;
(2016)
Human biomarkers: can they help us to develop a new tuberculosis vaccine?
Future microbiology, 11 (6).
pp. 781-787.
ISSN 1746-0913
DOI: https://doi.org/10.2217/fmb.16.15
Fletcher, Helen A;
Filali-Mouhim, Ali;
Nemes, Elisa;
Hawkridge, Anthony;
Keyser, Alana;
Njikan, Samuel;
Hatherill, Mark;
Scriba, Thomas J;
Abel, Brian;
Kagina, Benjamin M;
+7 more...
Veldsman, Ashley;
Agudelo, Nancy Marín;
Kaplan, Gilla;
Hussey, Gregory D;
Sekaly, Rafick-Pierre;
Hanekom, Willem A;
BCG study team;
(2016)
Human newborn bacille Calmette-Guérin vaccination and risk of tuberculosis disease: a case-control study.
BMC medicine, 14 (1).
76-.
ISSN 1741-7015
DOI: https://doi.org/10.1186/s12916-016-0617-3
Fletcher, Helen A;
Schrager, Lewis;
(2016)
TB vaccine development and the End TB Strategy: importance and current status.
Transactions of the Royal Society of Tropical Medicine and Hygiene, 110 (4).
pp. 212-218.
ISSN 0035-9203
DOI: https://doi.org/10.1093/trstmh/trw016
Fletcher, Helen A;
Snowden, Margaret A;
Landry, Bernard;
Rida, Wasima;
Satti, Iman;
Harris, Stephanie A;
Matsumiya, Magali;
Tanner, Rachel;
O'Shea, Matthew K;
Dheenadhayalan, Veerabadran;
+20 more...
Bogardus, Leah;
Stockdale, Lisa;
Marsay, Leanne;
Chomka, Agnieszka;
Harrington-Kandt, Rachel;
Manjaly-Thomas, Zita-Rose;
Naranbhai, Vivek;
Stylianou, Elena;
Darboe, Fatoumatta;
Penn-Nicholson, Adam;
Nemes, Elisa;
Hatherill, Mark;
Hussey, Gregory;
Mahomed, Hassan;
Tameris, Michele;
McClain, J Bruce;
Evans, Thomas G;
Hanekom, Willem A;
Scriba, Thomas J;
McShane, Helen;
(2016)
T-cell activation is an immune correlate of risk in BCG vaccinated infants.
Nature communications, 7 (1).
11290-.
ISSN 2041-1723
DOI: https://doi.org/10.1038/ncomms11290
Khan, Mishal S;
Fletcher, Helen;
London School of Hygiene and Tropical Medicine TB Centre Steerin;
Coker, Richard;
(2016)
Investments in tuberculosis research - what are the gaps?
BMC medicine, 14 (1).
123-.
ISSN 1741-7015
DOI: https://doi.org/10.1186/s12916-016-0644-0
Phillips, Patrick PJ;
Fletcher, Helen A;
Abubakar, Ibrahim;
Lipman, Marc CI;
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World TB Day 2016: an interview with leading experts in tuberculosis research.
BMC medicine, 14 (1).
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Zelmer, Andrea;
Knight, Gwenan M;
Prabowo, Satria Arief;
Stockdale, Lisa;
Evans, Thomas G;
Lindenstrøm, Thomas;
White, Richard G;
Fletcher, Helen;
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The TB vaccine H56+IC31 dose-response curve is peaked not saturating: Data generation for new mathematical modelling methods to inform vaccine dose decisions.
Vaccine, 34 (50).
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Human Immunology of Tuberculosis.
Microbiology spectrum, 4 (5).
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Smith, Steven G;
Zelmer, Andrea;
Blitz, Rose;
Fletcher, Helen A;
Dockrell, Hazel M;
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Polyfunctional CD4 T-cells correlate with in vitro mycobacterial growth inhibition following Mycobacterium bovis BCG-vaccination of infants.
Vaccine, 34 (44).
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DOI: https://doi.org/10.1016/j.vaccine.2016.09.002
Tanner, Rachel;
O'Shea, Matthew K;
Fletcher, Helen A;
McShane, Helen;
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In vitro mycobacterial growth inhibition assays: A tool for the assessment of protective immunity and evaluation of tuberculosis vaccine efficacy.
Vaccine, 34 (39).
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DOI: https://doi.org/10.1016/j.vaccine.2016.07.058
Vainieri, Maria L;
Blagborough, Andrew M;
MacLean, Adam L;
Haltalli, Myriam LR;
Ruivo, Nicola;
Fletcher, Helen A;
Stumpf, Michael PH;
Sinden, Robert E;
Celso, Cristina Lo;
(2016)
Systematic tracking of altered haematopoiesis during sporozoite-mediated malaria development reveals multiple response points.
Open biology, 6 (6).
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Zelmer, Andrea;
Tanner, Rachel;
Stylianou, Elena;
Damelang, Timon;
Morris, Sheldon;
Izzo, Angelo;
Williams, Ann;
Sharpe, Sally;
Pepponi, Ilaria;
Walker, Barry;
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Hokey, David A;
McShane, Helen;
Brennan, Michael;
Fletcher, Helen;
(2016)
A new tool for tuberculosis vaccine screening: Ex vivo Mycobacterial Growth Inhibition Assay indicates BCG-mediated protection in a murine model of tuberculosis.
BMC infectious diseases, 16 (1).
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DOI: https://doi.org/10.1186/s12879-016-1751-4
2015
Dunachie, Susanna;
Berthoud, Tamara;
Hill, Adrian VS;
Fletcher, Helen A;
(2015)
Transcriptional changes induced by candidate malaria vaccines and correlation with protection against malaria in a human challenge model.
Vaccine, 33 (40).
pp. 5321-5331.
ISSN 0264-410X
DOI: https://doi.org/10.1016/j.vaccine.2015.07.087
Dunachie, Susanna;
Hill, Adrian VS;
Fletcher, Helen A;
(2015)
Profiling the host response to malaria vaccination and malaria challenge.
Vaccine, 33 (40).
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ISSN 0264-410X
DOI: https://doi.org/10.1016/j.vaccine.2015.07.107
Fletcher, Helen A;
(2015)
Profiling the host immune response to tuberculosis vaccines.
Vaccine, 33 (40).
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ISSN 0264-410X
DOI: https://doi.org/10.1016/j.vaccine.2015.07.090
Full text not available from this repository.
Jenjaroen, Kemajittra;
Chumseng, Suchintana;
Sumonwiriya, Manutsanun;
Ariyaprasert, Pitchayanant;
Chantratita, Narisara;
Sunyakumthorn, Piyanate;
Hongsuwan, Maliwan;
Wuthiekanun, Vanaporn;
Fletcher, Helen A;
Teparrukkul, Prapit;
+3 more...
Limmathurotsakul, Direk;
Day, Nicholas PJ;
Dunachie, Susanna J;
(2015)
T-Cell Responses Are Associated with Survival in Acute Melioidosis Patients.
PLoS neglected tropical diseases, 9 (10).
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DOI: https://doi.org/10.1371/journal.pntd.0004152
Kaufmann, Stefan HE;
Fletcher, Helen A;
Guzmán, Carlos A;
Ottenhoff, Tom HM;
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Big Data in Vaccinology: Introduction and section summaries.
Vaccine, 33 (40).
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ISSN 0264-410X
DOI: https://doi.org/10.1016/j.vaccine.2015.04.078
Full text not available from this repository.
Naranbhai, Vivek;
Fletcher, Helen A;
Tanner, Rachel;
O'Shea, Matthew K;
McShane, Helen;
Fairfax, Benjamin P;
Knight, Julian C;
Hill, Adrian VS;
(2015)
Distinct Transcriptional and Anti-Mycobacterial Profiles of Peripheral Blood Monocytes Dependent on the Ratio of Monocytes: Lymphocytes.
EBioMedicine, 2 (11).
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ISSN 2352-3964
DOI: https://doi.org/10.1016/j.ebiom.2015.09.027
Rhodes, Sophie J;
Knight, Gwenan M;
Fielding, Katherine;
Scriba, Thomas J;
Pathan, Ansar A;
McShane, Helen;
Fletcher, Helen;
White, Richard G;
(2015)
Individual-level factors associated with variation in mycobacterial-specific immune response: Gender and previous BCG vaccination status.
Tuberculosis (Edinburgh, Scotland), 96.
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ISSN 1472-9792
DOI: https://doi.org/10.1016/j.tube.2015.10.002
Schito, Marco;
Migliori, Giovanni Battista;
Fletcher, Helen A;
McNerney, Ruth;
Centis, Rosella;
D'Ambrosio, Lia;
Bates, Matthew;
Kibiki, Gibson;
Kapata, Nathan;
Corrah, Tumena;
+6 more...
Bomanji, Jamshed;
Vilaplana, Cris;
Johnson, Daniel;
Mwaba, Peter;
Maeurer, Markus;
Zumla, Alimuddin;
(2015)
Perspectives on Advances in Tuberculosis Diagnostics, Drugs, and Vaccines.
Clinical infectious diseases, 61Supp (Suppl ).
S102-S118.
ISSN 1058-4838
DOI: https://doi.org/10.1093/cid/civ609
Full text not available from this repository.
Smith, Steven G;
Smits, Kaatje;
Joosten, Simone A;
van Meijgaarden, Krista E;
Satti, Iman;
Fletcher, Helen A;
Caccamo, Nadia;
Dieli, Francesco;
Mascart, Francoise;
McShane, Helen;
+3 more...
Dockrell, Hazel M;
Ottenhoff, Tom HM;
TBVI TB Biomarker Working Group;
(2015)
Intracellular Cytokine Staining and Flow Cytometry: Considerations for Application in Clinical Trials of Novel Tuberculosis Vaccines.
PloS one, 10 (9).
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DOI: https://doi.org/10.1371/journal.pone.0138042
2014
Dutruel, Céline;
Thole, Jelle;
Geels, Mark;
Mollenkopf, Hans-Joachim;
Ottenhoff, Tom;
Guzman, Carlos A;
Fletcher, Helen A;
Leroy, Odile;
Kaufmann, Stefan HE;
(2014)
TRANSVAC workshop on standardisation and harmonisation of analytical platforms for HIV, TB and malaria vaccines: 'how can big data help?'.
Vaccine, 32 (35).
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ISSN 0264-410X
DOI: https://doi.org/10.1016/j.vaccine.2014.06.014
Harris, Stephanie A;
Satti, Iman;
Matsumiya, Magali;
Stockdale, Lisa;
Chomka, Agnieszka;
Tanner, Rachel;
O'Shea, Matthew K;
Manjaly Thomas, Zita-Rose;
Tameris, Michele;
Mahomed, Hassan;
+4 more...
Scriba, Thomas J;
Hanekom, Willem A;
Fletcher, Helen A;
McShane, Helen;
(2014)
Process of assay selection and optimization for the study of case and control samples from a phase IIb efficacy trial of a candidate tuberculosis vaccine, MVA85A.
Clinical and vaccine immunology, 21 (7).
pp. 1005-1011.
ISSN 1556-6811
DOI: https://doi.org/10.1128/CVI.00128-14
Matsumiya, Magali;
Harris, Stephanie A;
Satti, Iman;
Stockdale, Lisa;
Tanner, Rachel;
O'Shea, Matthew K;
Tameris, Michelle;
Mahomed, Hassan;
Hatherill, Mark;
Scriba, Thomas J;
+3 more...
Hanekom, Willem A;
McShane, Helen;
Fletcher, Helen A;
(2014)
Inflammatory and myeloid-associated gene expression before and one day after infant vaccination with MVA85A correlates with induction of a T cell response.
BMC infectious diseases, 14 (1).
314-.
ISSN 1471-2334
DOI: https://doi.org/10.1186/1471-2334-14-314
Matsumiya, Magali;
Satti, Iman;
Chomka, Agnieszka;
Harris, Stephanie A;
Stockdale, Lisa;
Meyer, Joel;
Fletcher, Helen A;
McShane, Helen;
(2014)
Gene expression and cytokine profile correlate with mycobacterial growth in a human BCG challenge model.
The Journal of infectious diseases, 211 (9).
pp. 1499-1509.
ISSN 0022-1899
DOI: https://doi.org/10.1093/infdis/jiu615
Naranbhai, Vivek;
Kim, Soyeon;
Fletcher, Helen;
Cotton, Mark F;
Violari, Avy;
Mitchell, Charles;
Nachman, Sharon;
McSherry, George;
McShane, Helen;
Hill, Adrian VS;
+1 more...
Madhi, Shabir A;
(2014)
The association between the ratio of monocytes:lymphocytes at age 3 months and risk of tuberculosis (TB) in the first two years of life.
BMC medicine, 12 (1).
120-.
ISSN 1741-7015
DOI: https://doi.org/10.1186/s12916-014-0120-7
Naranbhai, Vivek;
Moodley, Dhayendre;
Chipato, Tsungai;
Stranix-Chibanda, Lynda;
Nakabaiito, Clemensia;
Kamateeka, Moreen;
Musoke, Philippa;
Manji, Karim;
George, Kathleen;
Emel, Lynda M;
+8 more...
Richardson, Paul;
Andrew, Philip;
Fowler, MaryGlenn;
Fletcher, Helen;
McShane, Helen;
Coovadia, Hoosen M;
Hill, Adrian VS;
HPTN 046 Protocol Team;
(2014)
The association between the ratio of monocytes: lymphocytes and risk of tuberculosis among HIV-infected postpartum women.
Journal of acquired immune deficiency syndromes (1999), 67 (5).
pp. 573-575.
ISSN 1525-4135
DOI: https://doi.org/10.1097/QAI.0000000000000353
Full text not available from this repository.
Tanner, Rachel;
Kakalacheva, Kristina;
Miller, Ellen;
Pathan, Ansar A;
Chalk, Rod;
Sander, Clare R;
Scriba, Tom;
Tameris, Michelle;
Hawkridge, Tony;
Mahomed, Hassan;
+5 more...
Hussey, Greg;
Hanekom, Willem;
Checkley, Anna;
McShane, Helen;
Fletcher, Helen A;
(2014)
Serum indoleamine 2,3-dioxygenase activity is associated with reduced immunogenicity following vaccination with MVA85A.
BMC infectious diseases, 14 (1).
660-.
ISSN 1471-2334
DOI: https://doi.org/10.1186/s12879-014-0660-7
2013
Fletcher, Helen A;
Tanner, Rachel;
Wallis, Robert S;
Meyer, Joel;
Manjaly, Zita-Rose;
Harris, Stephanie;
Satti, Iman;
Silver, Richard F;
Hoft, Dan;
Kampmann, Beate;
+6 more...
Walker, K Barry;
Dockrell, Hazel M;
Fruth, Uli;
Barker, Lew;
Brennan, Michael J;
McShane, Helen;
(2013)
Inhibition of mycobacterial growth in vitro following primary but not secondary vaccination with Mycobacterium bovis BCG.
Clinical and vaccine immunology, 20 (11).
pp. 1683-1689.
ISSN 1556-6811
DOI: https://doi.org/10.1128/CVI.00427-13
Full text not available from this repository.
Griffiths, Kristin L;
Stylianou, Elena;
Poyntz, Hazel C;
Betts, Gareth J;
Fletcher, Helen A;
McShane, Helen;
(2013)
Cholera toxin enhances vaccine-induced protection against Mycobacterium tuberculosis challenge in mice.
PloS one, 8 (10).
e78312-.
ISSN 1932-6203
DOI: https://doi.org/10.1371/journal.pone.0078312
Harris, Stephanie A;
Meyer, Joel;
Satti, Iman;
Marsay, Leanne;
Poulton, Ian D;
Tanner, Rachel;
Minassian, Angela M;
Fletcher, Helen A;
McShane, Helen;
(2013)
Evaluation of a human BCG challenge model to assess antimycobacterial immunity induced by BCG and a candidate tuberculosis vaccine, MVA85A, alone and in combination.
The Journal of infectious diseases, 209 (8).
pp. 1259-1268.
ISSN 0022-1899
DOI: https://doi.org/10.1093/infdis/jit647
Joosten, Simone A;
Fletcher, Helen A;
Ottenhoff, Tom HM;
(2013)
A helicopter perspective on TB biomarkers: pathway and process based analysis of gene expression data provides new insight into TB pathogenesis.
PloS one, 8 (9).
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ISSN 1932-6203
DOI: https://doi.org/10.1371/journal.pone.0073230
Marsay, Leanne;
Matsumiya, Magali;
Tanner, Rachel;
Poyntz, Hazel;
Griffiths, Kristin L;
Stylianou, Elena;
Marsh, Philip D;
Williams, Ann;
Sharpe, Sally;
Fletcher, Helen;
+1 more...
McShane, Helen;
(2013)
Mycobacterial growth inhibition in murine splenocytes as a surrogate for protection against Mycobacterium tuberculosis (M. tb).
Tuberculosis (Edinburgh, Scotland), 93 (5).
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ISSN 1472-9792
DOI: https://doi.org/10.1016/j.tube.2013.04.007
Matsumiya, Magali;
Stylianou, Elena;
Griffiths, Kristin;
Lang, Zoe;
Meyer, Joel;
Harris, Stephanie A;
Rowland, Rosalind;
Minassian, Angela M;
Pathan, Ansar A;
Fletcher, Helen;
+1 more...
McShane, Helen;
(2013)
Roles for Treg expansion and HMGB1 signaling through the TLR1-2-6 axis in determining the magnitude of the antigen-specific immune response to MVA85A.
PloS one, 8 (7).
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ISSN 1932-6203
DOI: https://doi.org/10.1371/journal.pone.0067922
Meyer, Joel;
Harris, Stephanie A;
Satti, Iman;
Poulton, Ian D;
Poyntz, Hazel C;
Tanner, Rachel;
Rowland, Rosalind;
Griffiths, Kristin L;
Fletcher, Helen A;
McShane, Helen;
(2013)
Comparing the safety and immunogenicity of a candidate TB vaccine MVA85A administered by intramuscular and intradermal delivery.
Vaccine, 31 (7).
pp. 1026-1033.
ISSN 0264-410X
DOI: https://doi.org/10.1016/j.vaccine.2012.12.042
Full text not available from this repository.
Naranbhai, Vivek;
Hill, Adrian VS;
Abdool Karim, Salim S;
Naidoo, Kogieleum;
Abdool Karim, Quarraisha;
Warimwe, George M;
McShane, Helen;
Fletcher, Helen;
(2013)
Ratio of monocytes to lymphocytes in peripheral blood identifies adults at risk of incident tuberculosis among HIV-infected adults initiating antiretroviral therapy.
The Journal of infectious diseases, 209 (4).
pp. 500-509.
ISSN 0022-1899
DOI: https://doi.org/10.1093/infdis/jit494
Warimwe, George M;
Fletcher, Helen A;
Olotu, Ally;
Agnandji, Selidji T;
Hill, Adrian VS;
Marsh, Kevin;
Bejon, Philip;
(2013)
Peripheral blood monocyte-to-lymphocyte ratio at study enrollment predicts efficacy of the RTS,S malaria vaccine: analysis of pooled phase II clinical trial data.
BMC medicine, 11 (1).
184-.
ISSN 1741-7015
DOI: https://doi.org/10.1186/1741-7015-11-184
Warimwe, George M;
Murungi, Linda M;
Kamuyu, Gathoni;
Nyangweso, George M;
Wambua, Juliana;
Naranbhai, Vivek;
Fletcher, Helen A;
Hill, Adrian VS;
Bejon, Philip;
Osier, Faith HA;
+1 more...
Marsh, Kevin;
(2013)
The ratio of monocytes to lymphocytes in peripheral blood correlates with increased susceptibility to clinical malaria in Kenyan children.
PloS one, 8 (2).
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ISSN 1932-6203
DOI: https://doi.org/10.1371/journal.pone.0057320
2012
Pathan, Ansar A;
Minassian, Angela M;
Sander, Clare R;
Rowland, Rosalind;
Porter, David W;
Poulton, Ian D;
Hill, Adrian VS;
Fletcher, Helen A;
McShane, Helen;
(2012)
Effect of vaccine dose on the safety and immunogenicity of a candidate TB vaccine, MVA85A, in BCG vaccinated UK adults.
Vaccine, 30 (38).
pp. 5616-5624.
ISSN 0264-410X
DOI: https://doi.org/10.1016/j.vaccine.2012.06.084
2011
Berthoud, Tamara K;
Hamill, Matthew;
Lillie, Patrick J;
Hwenda, Lenias;
Collins, Katharine A;
Ewer, Katie J;
Milicic, Anita;
Poyntz, Hazel C;
Lambe, Teresa;
Fletcher, Helen A;
+2 more...
Hill, Adrian VS;
Gilbert, Sarah C;
(2011)
Potent CD8+ T-cell immunogenicity in humans of a novel heterosubtypic influenza A vaccine, MVA-NP+M1.
Clinical infectious diseases, 52 (1).
pp. 1-7.
ISSN 1058-4838
DOI: https://doi.org/10.1093/cid/ciq015
Griffiths, K;
Stylianou, E;
Poyntz, H;
Betts, G;
Fletcher, H;
McShane, H;
Beveridge, N;
Minassian, A;
Rowland, R;
Poulton, I;
+22 more...
Satti, I;
Harris, S;
Poyntz, H;
Hamill, M;
Griffiths, K;
Sander, C;
Ambrozak, D;
Price, D;
Hill, B;
Casazza, J;
Douek, D;
Koup, R;
Roederer, M;
Winston, A;
Ross, J;
Sherrad, J;
Rooney, G;
Williams, N;
Lawrie, A;
Fletcher, H;
Pathan, A;
McShane, H;
(2011)
Th1/Th17 cell induction following vaccination with the novel tuberculosis vaccine MVA85A and their role in Mycobacterium tuberculosis challenge
CD4 T cell response to MVA85A vaccination against Mycobacterium tuberculosis in healthy HIV-infected adults SO IMMUNOLOGY CT Annual Congress of the British-Society-for-Immunology CY DEC 05-08, 2011 CL Liverpool, ENGLAND SP British Soc Immunol.
[Conference or Workshop Item]
https://researchonline.lshtm.ac.uk/id/eprint/2729027
Full text not available from this repository.
Griffiths, Kristin L;
Pathan, Ansar A;
Minassian, Angela M;
Sander, Clare R;
Beveridge, Natalie ER;
Hill, Adrian VS;
Fletcher, Helen A;
McShane, Helen;
(2011)
Th1/Th17 cell induction and corresponding reduction in ATP consumption following vaccination with the novel Mycobacterium tuberculosis vaccine MVA85A.
PloS one, 6 (8).
e23463-.
ISSN 1932-6203
DOI: https://doi.org/10.1371/journal.pone.0023463
Kasprowicz, Victoria O;
Mitchell, Jessica E;
Chetty, Shivan;
Govender, Pamla;
Huang, Kuan-Hsiang Gary;
Fletcher, Helen A;
Webster, Daniel P;
Brown, Sebastian;
Kasmar, Anne;
Millington, Kerry;
+8 more...
Day, Cheryl L;
Mkhwanazi, Nompumelelo;
McClurg, Cheryl;
Chonco, Fundisiwe;
Lalvani, Ajit;
Walker, Bruce D;
Ndung'u, Thumbi;
Klenerman, Paul;
(2011)
A molecular assay for sensitive detection of pathogen-specific T-cells.
PloS one, 6 (8).
e20606-.
ISSN 1932-6203
DOI: https://doi.org/10.1371/journal.pone.0020606
Minassian, Angela M;
Rowland, Rosalind;
Beveridge, Natalie ER;
Poulton, Ian D;
Satti, Iman;
Harris, Stephanie;
Poyntz, Hazel;
Hamill, Matthew;
Griffiths, Kristin;
Sander, Clare R;
+16 more...
Ambrozak, David R;
Price, David A;
Hill, Brenna J;
Casazza, Joseph P;
Douek, Daniel C;
Koup, Richard A;
Roederer, Mario;
Winston, Alan;
Ross, Jonathan;
Sherrard, Jackie;
Rooney, Guy;
Williams, Nicola;
Lawrie, Alison M;
Fletcher, Helen A;
Pathan, Ansar A;
McShane, Helen;
(2011)
A Phase I study evaluating the safety and immunogenicity of MVA85A, a candidate TB vaccine, in HIV-infected adults.
BMJ open, 1 (2).
e000223-.
ISSN 2044-6055
DOI: https://doi.org/10.1136/bmjopen-2011-000223
Moore, CE;
Hennig, BJ;
Perrett, KP;
Hoe, JC;
Lee, SJ;
Fletcher, H;
Brocklebank, D;
O'Connor, D;
Snape, MD;
Hall, AJ;
+3 more...
Segal, S;
Hill, AVS;
Pollard, AJ;
(2011)
Single Nucleotide Polymorphisms in the Toll-Like Receptor 3 and CD44 Genes Are Associated with Persistence of Vaccine-Induced Immunity to the Serogroup C Meningococcal Conjugate Vaccine.
[Conference or Workshop Item]
https://doi.org/10.1128/CVI.05379-11
Full text not available from this repository.
2010
Dunachie, Susanna J;
Berthoud, Tamara;
Keating, Sheila M;
Hill, Adrian VS;
Fletcher, Helen A;
(2010)
MIG and the regulatory cytokines IL-10 and TGF-β1 correlate with malaria vaccine immunogenicity and efficacy.
PloS one, 5 (9).
e12557-.
ISSN 1932-6203
DOI: https://doi.org/10.1371/journal.pone.0012557
Lienhardt, Christian;
Fielding, Katherine;
Hane, Abdoul A;
Niang, Aliou;
Ndao, Cheikh T;
Karam, Farba;
Fletcher, Helen;
Mbow, Fatou;
Gomis, Jules-François;
Diadhiou, Raymond;
+3 more...
Toupane, Maxime;
Dieye, Tandakha;
Mboup, Souleymane;
(2010)
Evaluation of the prognostic value of IFN-gamma release assay and tuberculin skin test in household contacts of infectious tuberculosis cases in Senegal.
PloS one, 5 (5).
e10508-.
ISSN 1932-6203
DOI: https://doi.org/10.1371/journal.pone.0010508
de Cassan, Simone C;
Pathan, Ansar A;
Sander, Clare R;
Minassian, Angela;
Rowland, Rosalind;
Hill, Adrian VS;
McShane, Helen;
Fletcher, Helen A;
(2010)
Investigating the induction of vaccine-induced Th17 and regulatory T cells in healthy, Mycobacterium bovis BCG-immunized adults vaccinated with a new tuberculosis vaccine, MVA85A.
Clinical and vaccine immunology, 17 (7).
pp. 1066-1073.
ISSN 1556-6811
DOI: https://doi.org/10.1128/CVI.00047-10
Full text not available from this repository.
2009
Berthoud, Tamara K;
Dunachie, Susanna J;
Todryk, Stephen;
Hill, Adrian VS;
Fletcher, Helen A;
(2009)
MIG (CXCL9) is a more sensitive measure than IFN-gamma of vaccine induced T-cell responses in volunteers receiving investigated malaria vaccines.
Journal of immunological methods, 340 (1).
pp. 33-41.
ISSN 0022-1759
DOI: https://doi.org/10.1016/j.jim.2008.09.021
Berthoud, Tamara K;
Fletcher, Helen;
Porter, David;
Thompson, Fiona;
Hill, Adrian VS;
Todryk, Stephen M;
(2009)
Comparing human T cell and NK cell responses in viral-based malaria vaccine trials.
Vaccine, 28 (1).
pp. 21-27.
ISSN 0264-410X
DOI: https://doi.org/10.1016/j.vaccine.2009.09.132
Full text not available from this repository.
Fletcher, Helen A;
Hawkridge, Tony;
McShane, Helen;
(2009)
A New Vaccine for Tuberculosis: The Challenges of Development and Deployment.
Journal of bioethical inquiry, 6 (2).
pp. 219-228.
ISSN 1176-7529
DOI: https://doi.org/10.1007/s11673-009-9153-6
Fletcher, Helen A;
Keyser, Alana;
Bowmaker, Mark;
Sayles, Peter C;
Kaplan, Gilla;
Hussey, Greg;
Hill, Adrian VS;
Hanekom, Willem A;
(2009)
Transcriptional profiling of mycobacterial antigen-induced responses in infants vaccinated with BCG at birth.
BMC medical genomics, 2 (1).
10-.
ISSN 1755-8794
DOI: https://doi.org/10.1186/1755-8794-2-10
Mwacharo, Jedidah;
Dunachie, Susanna J;
Kai, Oscar;
Hill, Adrian VS;
Bejon, Philip;
Fletcher, Helen A;
(2009)
Quantitative PCR evaluation of cellular immune responses in Kenyan children vaccinated with a candidate malaria vaccine.
PloS one, 4 (12).
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ISSN 1932-6203
DOI: https://doi.org/10.1371/journal.pone.0008434
Whelan, Kathryn T;
Pathan, Ansar A;
Sander, Clare R;
Fletcher, Helen A;
Poulton, Ian;
Alder, Nicola C;
Hill, Adrian VS;
McShane, Helen;
(2009)
Safety and immunogenicity of boosting BCG vaccinated subjects with BCG: comparison with boosting with a new TB vaccine, MVA85A.
PloS one, 4 (6).
e5934-.
ISSN 1932-6203
DOI: https://doi.org/10.1371/journal.pone.0005934
2008
Beveridge, Natalie ER;
Fletcher, Helen A;
Hughes, Jane;
Pathan, Ansar A;
Scriba, Thomas J;
Minassian, Angela;
Sander, Clare R;
Whelan, Kathryn T;
Dockrell, Hazel M;
Hill, Adrian VS;
+2 more...
Hanekom, Willem A;
McShane, Helen;
(2008)
A comparison of IFNgamma detection methods used in tuberculosis vaccine trials.
Tuberculosis (Edinburgh, Scotland), 88 (6).
pp. 631-640.
ISSN 1472-9792
DOI: https://doi.org/10.1016/j.tube.2008.06.005
Full text not available from this repository.
Brookes, Roger H;
Hill, Philip C;
Owiafe, Patrick K;
Ibanga, Hannah B;
Jeffries, David J;
Donkor, Simon A;
Fletcher, Helen A;
Hammond, Abdulrahman S;
Lienhardt, Christian;
Adegbola, Richard A;
+2 more...
McShane, Helen;
Hill, Adrian VS;
(2008)
Safety and immunogenicity of the candidate tuberculosis vaccine MVA85A in West Africa.
PloS one, 3 (8).
e2921-.
ISSN 1932-6203
DOI: https://doi.org/10.1371/journal.pone.0002921
Fletcher, Helen A;
Pathan, Ansar A;
Berthoud, Tamara K;
Dunachie, Susanna J;
Whelan, Kathryn T;
Alder, Nicola C;
Sander, Clare R;
Hill, Adrian VS;
McShane, Helen;
(2008)
Boosting BCG vaccination with MVA85A down-regulates the immunoregulatory cytokine TGF-beta1.
Vaccine, 26 (41).
pp. 5269-5275.
ISSN 0264-410X
DOI: https://doi.org/10.1016/j.vaccine.2008.07.040
Hanekom, Willem A;
Dockrell, Hazel M;
Ottenhoff, Tom HM;
Doherty, T Mark;
Fletcher, Helen;
McShane, Helen;
Weichold, Frank F;
Hoft, Dan F;
Parida, Shreemanta K;
Fruth, Uli J;
(2008)
Immunological outcomes of new tuberculosis vaccine trials: WHO panel recommendations.
PLoS medicine, 5 (7).
e145-.
ISSN 1549-1277
DOI: https://doi.org/10.1371/journal.pmed.0050145
Hawkridge, Tony;
Scriba, Thomas J;
Gelderbloem, Sebastian;
Smit, Erica;
Tameris, Michele;
Moyo, Sizulu;
Lang, Trudie;
Veldsman, Ashley;
Hatherill, Mark;
Merwe, Linda van der;
+6 more...
Fletcher, Helen A;
Mahomed, Hassan;
Hill, Adrian VS;
Hanekom, Willem A;
Hussey, Gregory D;
McShane, Helen;
(2008)
Safety and immunogenicity of a new tuberculosis vaccine, MVA85A, in healthy adults in South Africa.
The Journal of infectious diseases, 198 (4).
pp. 544-552.
ISSN 0022-1899
DOI: https://doi.org/10.1086/590185
Full text not available from this repository.
Karam, Farba;
Mbow, Fatou;
Fletcher, Helen;
Senghor, Cheikh S;
Coulibaly, Koura D;
LeFevre, Andrea M;
Ngom Gueye, Ndeye F;
Dieye, Tandakha;
Sow, Papa S;
Mboup, Souleymane;
+1 more...
Lienhardt, Christian;
(2008)
Sensitivity of IFN-gamma release assay to detect latent tuberculosis infection is retained in HIV-infected patients but dependent on HIV/AIDS progression.
PloS one, 3 (1).
e1441-.
ISSN 1932-6203
DOI: https://doi.org/10.1371/journal.pone.0001441
2007
Fletcher, Helen A;
(2007)
Correlates of immune protection from tuberculosis.
Current molecular medicine, 7 (3).
pp. 319-325.
ISSN 1566-5240
DOI: https://doi.org/10.2174/156652407780598520
Full text not available from this repository.
Pathan, Ansar A;
Sander, Clare R;
Fletcher, Helen A;
Poulton, Ian;
Alder, Nicola C;
Beveridge, Natalie ER;
Whelan, Kathryn T;
Hill, Adrian VS;
McShane, Helen;
(2007)
Boosting BCG with recombinant modified vaccinia ankara expressing antigen 85A: different boosting intervals and implications for efficacy trials.
PloS one, 2 (10).
e1052-.
ISSN 1932-6203
DOI: https://doi.org/10.1371/journal.pone.0001052
2006
Demissie, Abebech;
Leyten, Eliane MS;
Abebe, Markos;
Wassie, Liya;
Aseffa, Abraham;
Abate, Getahun;
Fletcher, Helen;
Owiafe, Patrick;
Hill, Philip C;
Brookes, Roger;
+8 more...
Rook, Graham;
Zumla, Alimuddin;
Arend, Sandra M;
Klein, Michel;
Ottenhoff, Tom HM;
Andersen, Peter;
Doherty, T Mark;
VACSEL Study Group;
(2006)
Recognition of stage-specific mycobacterial antigens differentiates between acute and latent infections with Mycobacterium tuberculosis.
Clinical and vaccine immunology, 13 (2).
pp. 179-186.
ISSN 1556-6811
DOI: https://doi.org/10.1128/CVI.13.2.179-186.2006
Full text not available from this repository.
Fletcher, Helen;
McShane, Helen;
(2006)
Tuberculosis vaccines: current status and future prospects.
Expert opinion on emerging drugs, 11 (2).
pp. 207-215.
ISSN 1472-8214
DOI: https://doi.org/10.1517/14728214.11.2.207
Full text not available from this repository.
Ibanga, Hannah B;
Brookes, Roger H;
Hill, Philip C;
Owiafe, Patrick K;
Fletcher, Helen A;
Lienhardt, Christian;
Hill, Adrian VS;
Adegbola, Richard A;
McShane, Helen;
(2006)
Early clinical trials with a new tuberculosis vaccine, MVA85A, in tuberculosis-endemic countries: issues in study design.
The Lancet infectious diseases, 6 (8).
pp. 522-528.
ISSN 1473-3099
DOI: https://doi.org/10.1016/S1473-3099(06)70552-7
Full text not available from this repository.
Sander, CR;
Tchilian, E;
Dahm-Vicker, M;
Fletcher, H;
McShane, H;
Hill, AVS;
(2006)
New tuberculosis vaccines can diminish as well as enhance BCG induced protection: Results from a murine model SO THORAX CT Winter Meeting of the British-Thoracic-Society/British-Lung-Foundation (BTS/BLF).
[Conference or Workshop Item]
https://researchonline.lshtm.ac.uk/id/eprint/2729022
Full text not available from this repository.
2005
McShane, Helen;
Pathan, Ansar A;
Sander, Clare R;
Goonetilleke, Nilu P;
Fletcher, Helen A;
Hill, Adrian VS;
(2005)
Boosting BCG with MVA85A: the first candidate subunit vaccine for tuberculosis in clinical trials.
Tuberculosis (Edinburgh, Scotland), 85 (1-2).
pp. 47-52.
ISSN 1472-9792
DOI: https://doi.org/10.1016/j.tube.2004.09.015
Full text not available from this repository.
Walther, Michael;
Tongren, Jon Eric;
Andrews, Laura;
Korbel, Daniel;
King, Elizabeth;
Fletcher, Helen;
Andersen, Rikke F;
Bejon, Philip;
Thompson, Fiona;
Dunachie, Susanna J;
+6 more...
Edele, Fanny;
de Souza, J Brian;
Sinden, Robert E;
Gilbert, Sarah C;
Riley, Eleanor M;
Hill, Adrian VS;
(2005)
Upregulation of TGF-beta, FOXP3, and CD4+CD25+ regulatory T cells correlates with more rapid parasite growth in human malaria infection.
Immunity, 23 (3).
pp. 287-296.
ISSN 1074-7613
DOI: https://doi.org/10.1016/j.immuni.2005.08.006
Full text not available from this repository.
2004
Demissie, Abebech;
Abebe, Markos;
Aseffa, Abraham;
Rook, Graham;
Fletcher, Helen;
Zumla, Alimuddin;
Weldingh, Karin;
Brock, Inger;
Andersen, Peter;
Doherty, T Mark;
+1 more...
VACSEL Study Group;
(2004)
Healthy individuals that control a latent infection with Mycobacterium tuberculosis express high levels of Th1 cytokines and the IL-4 antagonist IL-4delta2.
Journal of immunology (Baltimore, Md, 172 (11).
pp. 6938-6943.
ISSN 0022-1767
DOI: https://doi.org/10.4049/jimmunol.172.11.6938
Full text not available from this repository.
Fletcher, Helen A;
Owiafe, Patrick;
Jeffries, David;
Hill, Philip;
Rook, Graham AW;
Zumla, Alimuddin;
Doherty, T Mark;
Brookes, Roger H;
Vacsel Study Group;
(2004)
Increased expression of mRNA encoding interleukin (IL)-4 and its splice variant IL-4delta2 in cells from contacts of Mycobacterium tuberculosis, in the absence of in vitro stimulation.
Immunology, 112 (4).
pp. 669-673.
ISSN 0019-2805
DOI: https://doi.org/10.1111/j.1365-2567.2004.01922.x
Full text not available from this repository.
McShane, Helen;
Pathan, Ansar A;
Sander, Clare R;
Keating, Sheila M;
Gilbert, Sarah C;
Huygen, Kris;
Fletcher, Helen A;
Hill, Adrian VS;
(2004)
Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans.
Nature medicine, 10 (11).
pp. 1240-1244.
ISSN 1078-8956
DOI: https://doi.org/10.1038/nm1128
Full text not available from this repository.
2003
Fletcher, Helen A;
Donoghue, Helen D;
Holton, John;
Pap, Ildikó;
Spigelman, Mark;
(2003)
Widespread occurrence of Mycobacterium tuberculosis DNA from 18th-19th century Hungarians.
American journal of physical anthropology, 120 (2).
pp. 144-152.
ISSN 0002-9483
DOI: https://doi.org/10.1002/ajpa.10114
Full text not available from this repository.
Fletcher, Helen A;
Donoghue, Helen D;
Taylor, G Michael;
van der Zanden, Adri GM;
Spigelman, Mark;
(2003)
Molecular analysis of Mycobacterium tuberculosis DNA from a family of 18th century Hungarians.
Microbiology (Reading, England), 149 (Pt 1).
pp. 143-151.
ISSN 1350-0872
DOI: https://doi.org/10.1099/mic.0.25961-0
Full text not available from this repository.
2002
Ferns, R Bridget;
Fletcher, Helen;
Bradley, Susan;
Mackinnon, Stephen;
Hunt, Chris;
Tedder, Richard S;
(2002)
The prospective evaluation of a nested polymerase chain reaction assay for the early detection of Aspergillus infection in patients with leukaemia or undergoing allograft treatment.
British journal of haematology, 119 (3).
pp. 720-725.
ISSN 0007-1048
DOI: https://doi.org/10.1046/j.1365-2141.2002.03862.x
Full text not available from this repository.
Kasolo, Francis;
Lishimpi, Kennedy;
Chintu, Chifumbe;
Mwaba, Peter;
Mudenda, Victor;
Maswahu, Daniel;
Terunuma, Hiroshi;
Fletcher, Helen;
Nunn, Andrew;
Lucas, Sebastian;
+1 more...
Zumla, Alimuddin;
(2002)
Identification of Pneumocystis carinii DNA by polymerase chain reaction in necropsy lung samples from children dying of respiratory tract illnesses.
The Journal of pediatrics, 140 (3).
pp. 367-369.
ISSN 0022-3476
DOI: https://doi.org/10.1067/mpd.2002.122468
Full text not available from this repository.
2001
Fletcher, HA;
(2001)
Molecular epidemiology of tuberculosis: recent developments and applications.
Current opinion in pulmonary medicine, 7 (3).
pp. 154-159.
ISSN 1070-5287
DOI: https://doi.org/10.1097/00063198-200105000-00007
Full text not available from this repository.